This summer is full of big action films, pricey sequels and 3-D extravaganzas. But one of the most buzzed-about films is a low-budget comedy called MacGruber. According to the Los Angeles Times, the film “brought down the house” when it was screened recently at the South by Southwest festival in Austin, Tex.

MacGruber, starring Saturday Night Live cast member Will Forte, is based on an SNL sketch about a MacGyver-esque agent who tries (in vain) to defuse bombs using ordinary household items. Forte was able to make the film edgier than the sketches (including a villain named Dieter Von Cunth), earning MacGruber an R rating.

If the film is a box-office success when it comes Forte could be on his way to joining the pantheon of SNL members who have succeeded at the box office. Many have tried to make the leap, but only a few have become box-office heroes.

Topping our list is Eddie Murphy. The comedian performed on SNL during some of its strongest seasons from 1980 to 1984. From there he went on to star in successful movies like Beverly Hills Cop, Coming to America and The Nutty Professor.

But it was his work in the animated Shrek series from DreamWorks Animation that has propelled him to No. 1 on our list. As the voice of Donkey, Murphy has become a key player in a franchise that has earned $2.2 billion at the box office so far. That total will jump later this month when the final film, Shrek Forever After, hits theaters in 3-D (opposite MacGruber, which will likely attract a more mature audience).

Over the last 10 years Murphy’s films have earned $3.6 billion at the box office. In addition to the Shrek films, he’s starred in box-office winners like Daddy Day Care and Dr. Dolittle 2. Lately Murphy’s box-office prowess has come into question, though, with a series of duds including Meet Dave and Imagine That, both of which failed to earn back their production budgets at the box office.

To compile our list we looked at SNL cast members’ film work over the last 10 years and added up global box-office earnings. Usually we don’t count animation roles in these sorts of lists because the audiences often don’t know or care who is voicing the characters. We made an exception this time because Murphy and Mike Myers are so inextricably linked with the Shrek movies that the series has become as much about the actors as about the characters (which is why Murphy, Myers and Cameron Diaz earn upwards of $10 million each for their work in each film).

The Shrek films helped land Myers, who voices the green ogre, in second place with $3 billion. Like Murphy, Myers has had a rough couple of years outside of the Shrek films, culminating with the 2008 box-office bomb The Love Guru. From Viacom studio Paramount Pictures, the comedy earned only $40 million at the global box office on an estimated budget of $60 million.

In third place is Adam Sandler. Few actors are as successful at the box office as Sandler. His films have earned $2.1 billion in the last 10 years without the help of a successful animated franchise like Shrek. His 2008 film Bedtime Stories earned $213 million at the global box office.

Robert Downey Jr. ranks fourth with $2 billion. The Iron Man actor was only a cast member for one year in 1985 when the show was in a ratings free fall. After his run on SNL he appeared in well-received movies like Less Than Zero and Chaplin, but struggles with drugs temporarily derailed his career. In the last few years Downey has enjoyed one of the greatest career resurgences Hollywood has seen with hits like Iron Man and Sherlock Holmes. Iron Man 2 last weekend had the fifth-highest opening of all time, taking in $134 million at the U.S. box office.

The only woman who makes our list is Tina Fey, whose films have earned $340 million at the box office, ranking her ninth. Her most recent movie, Date Night, is also her most successful, with $116 million at the box office so far.