The Vice Chancellor of the University of Port Harcourt (UNIPORT), Prof Owunari Georgewill, last Thursday received the inaugural lecture brochure from the Inaugural Lecturer, Professor Udeme Georgewill, during a ceremony at the university’s Centre of Excellence attended by academics, researchers, students, and distinguished guests.
Delivering her lecture, Professor Udeme Georgewill described the occasion as the culmination of years of dedicated research, teaching, and service to humanity. He explained that his work as a pharmacologist has consistently focused on finding practical, affordable, and scientifically sound solutions to health challenges that disproportionately affect developing countries, particularly malaria, which remains one of Nigeria’s most pressing public health concerns.
She noted that Nigeria continues to bear one of the heaviest malaria burdens globally, accounting for a significant percentage of worldwide cases and deaths. The disease, largely caused by the Plasmodium falciparum parasite and transmitted through Anopheles mosquitoes, remains especially dangerous for children under five years and pregnant women, threatening not only present populations but unborn generations. Despite years of intervention efforts, malaria continues to strain families, health systems, and the national economy.
Prof Georgewill empha-sised that while Artemisinin-based Combination Therapies such as Artemether-Lumefantrine remain the gold standard for malaria treatment, emerging resistance patterns pose a serious challenge. He explained that drug resistance is a survival mechanism of the parasite, enabling it to adapt and reduce the effectiveness of medications designed to eliminate it. According to her, instances where patients do not feel better after initial treatment sometimes lead to repeated dosing or the search for injectable alternatives, practices that can worsen resistance and complicate treatment outcomes.
Against this backdrop, she advocated strongly for drug repurposing as a strategic and urgent response. Drug repurposing, he explained, involves identifying new therapeutic uses for already approved and widely available medications. He likened the concept to “old wine in new wineskins,” stressing that medicines already proven safe for certain conditions can be carefully re-evaluated and optimised for new roles in malaria management. This approach, she argued, offers advantages such as reduced research timelines, lower development costs, and faster clinical application compared to developing entirely new drugs from scratch.
She disclosed that her research had progressed from laboratory investigations to clinical evaluations, where his team is studying combinations involving Artemether-Lumefantrine and Ivermectin to determine their effectiveness in improving treatment outcomes and possibly reducing transmission. Clinical trials are ongoing, and findings will be communicated upon completion of regulatory processes. However, he cautioned strongly against self-medication, warning that misuse of drugs without proper diagnosis and prescription can lead to organ damage, treatment failure, and increased resistance.
Referencing global health commitments, Prof Georgewill highlighted Sustainable Development Goal 3.3, which seeks to end epidemics of malaria and other major infectious diseases by 2030. She questioned whether the goal remains attainable under current realities, especially with growing resistance and funding gaps. He also referred to strategies of the World Health Organisation aimed at drastically reducing malaria incidence and mortality while pushing toward elimination in several countries.
Looking ahead, she revealed that her team is building comprehensive research databases to support artificial intelligence-driven drug repurposing. He stressed that the integration of artificial intelligence, molecular docking, and advanced screening technologies is transforming global drug discovery, and Nigerian researchers must be equipped to participate competitively in this evolving scientific landscape.
In her recommendations, she called for the establishment of a National Centre for Drug Repurposing to coordinate research efforts and leverage artificial intelligence in identifying new indications for existing medicines. He urged policymakers to simplify and accelerate the translation of laboratory discoveries into clinical application, ensuring that scientific breakthroughs benefit the public more efficiently. She also appealed to the university and relevant authorities to increase funding and modernise laboratory infrastructure, including high-throughput screening facilities, to strengthen Nigeria’s position in global biomedical research.
The lecture concluded with expressions of gratitude to God, the university leadership, colleagues, students, and guests, as the event underscored the University of Port Harcourt’s commitment to research excellence and its role in addressing critical public health challenges facing Nigeria and the wider world.