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US, Nigeria Find Way To Give Better Estimate Of COVID-19 Sero-Prevalence
In continuation of United States Government support for Nigeria’s conduct of a household survey that determines the extent of COVID-19 transmission in the country, a new study by a team of U.S. and Nigerian scientists has reaffirmed the importance of validating SARS-CoV-2 assays using locally obtained samples to assess COVID-19 exposure in the population.
Therefore, the researchers conducted a laboratory-based investigation to validate SARS-CoV-2 assays using samples from COVID-19 survivors and other archived pre-pandemic samples available in Nigeria.
In the study tagged, ‘Validation of xMAP SARS-CoV-2 Multi-Antigen IgG assay in Nigeria’ (plos.org) published in the journal PLOS ONE, the researchers collected samples from individuals at different time points after the patients’ initial COVID-19 RT-PCR (Reverse Transcription Polymerase Chain Reaction) positive result.
In addition, the researchers used archived plasma specimens stored before October, 2019 and specimens from the 2018 US-supported Nigeria HIV/AIDS Indicator and Impact Survey (NAIIS). Over 100 SARS-CoV-2 positive specimens and about 300 archived specimens were used to evaluate the assays’ sensitivity and specificity, two crucial indicators of the accuracy of tests results.
The team initially validated four SARS-CoV-2 serological assays, which show lower sensitivity than the manufacturers’ results.
Similarly, two assays targeting the most crucial structural components of SARS-CoV-2 (Nucleocapsid protein) indicated moderate to substantial cross-reactivity.
Cross-reactivity is the presence of other pathogens in the samples, thereby affecting the test outcomes.
Dr. Nnaemeka Iriemenam is the paper’s lead author and Deputy Chief of the US-CDC Nigeria Laboratory Branch.
He said it is vital for countries preparing for COVID-19 sero-surveillance to validate SARS-CoV-2 serology assay using in-country specimens.
The assays need to reflect the serologic profile of the population being tested to avoid wrong estimates.
This latest study follows previous studies by the same team.
The conclusions are consistent with the Validation of Commercial SARS-CoV-2 Immunoassays in a Nigerian Population study published in Microbiology Spectrum 10.1128/Spectrum.00680-21.
It is also in line with the Cross-Reactivity of Two SARS-CoV-2 Serological Assays in a Setting Where Malaria Is Endemic, published in American Society for Microbiology’s Journal of Clinical Microbiology 10.1128/JCM.00514-21.
These studies show the strong collaboration between Nigeria and U.S. researchers and further highlight U.S. Government’s technical assistance to Nigeria’s COVID-19 pandemic response. In addition to collaborative research to understand the virus epidemiology and its spread among the population, the United States is at the forefront of providing vaccines and other technical assistance to Nigeria.
The Governor of Rivers State, Sir Siminalayi Fubara, has begun the celebration of Nigeria’s 65th Independence anniversary with a Juma’at service where prayers were offered for the progress of the state and Nigeria.
Governor Fubara, who advocated for peace and unity of Nigeria during the prayers on Friday at the Rivers State Central Mosque, Port Harcourt, indicated that without peace, the accelerated development of Nigeria will remain in a limbo.
Governor Fubara, who was represented by Alhaji Abdurrazaq Diepriye, therefore urged citizens to remain patriotic.
According to him, “Allah has brought us this far. Without peace, we can not have progress and economic development. I call on all citizens irrespective of creed or tribe to remain patriotic.”
He thanked President Bola Tinubu for restoring peace in Rivers State while also using the forum to appreciate security agencies for their relentless effort in upholding the peace and unity of Rivers State and Nigeria.
The Chief Imam of Rivers State Central Mosque, Imam Ibrahim Yaloo, admonished Moslem faithful to always speak the truth, adding that those who obey Allah will be directed to good deeds and their sins forgiven.
Prayers were offered for Rivers State and Nigeria.
Other activities to mark the 65th Independence anniversary in the state include an Inter-denominational Church Thanksgiving Service on Sunday, 28th September and Parade Ceremony on Wednesday, 1st October.
Vice-President Kashim Shettima departed New York on Sunday after representing President Bola Tinubu at the 80th session of the United Nations General Assembly.
In a statement released on Sunday by the VP media aide, Stanley Nkwocha, the Vice President is now headed to Germany, where he will hold strategic meetings with officials of Deutsche Bank.
The statement read, “Vice President Kashim Shettima has departed New York, United States, after successfully representing President Bola Ahmed Tinubu, GCFR, at the 80th Session of the United Nations General Assembly.
“During his participation at UNGA 80, VP Shettima secured UN Secretary-General António Guterres’ commendation for Nigeria’s bid for a permanent UN Security Council seat.
“He also showcased Nigeria’s $200 billion energy transition opportunity to global investors and strengthened strategic partnerships with the UK on trade, defence, and migration issues.”
Nkwocha added that the VP delivered Tinubu’s national statement, calling for UN reforms and a permanent seat for Nigeria at the UN Security Council, and “demanded Africa’s control over its $700 billion mineral wealth, and digital inclusion initiatives.”
“He also engaged with the Gates Foundation on healthcare and education expansion, positioning Nigeria as the natural hub for the African Continental Free Trade Area’s $3.4 trillion market.
“VP Shettima was seen off at John F. Kennedy International Airport, New York, by cabinet Ministers who were part of the UNGA 80 delegation and Nigerian Mission officials.”
The aide noted that Shettima will return to Nigeria immediately after his engagements in Germany.
The Tide source recalls that the VP departed Abuja, yesterday.
He led other Nigerian officials at the Assembly.
As part of Nigeria’s 65th Independence anniversary celebration, the Federal Government held a special thanksgiving service on Sunday at the National Ecumenical Centre in Abuja to offer prayers and give thanks for the nation.
The event drew top government officials and security chiefs, including Senate President Godswill Akpabio and Secretary to the Government of the Federation, George Akume, as well as their spouses.
Other notable guests included Finance Minister and Coordinating Minister of the Economy Wale Edun, former Plateau State Governor, Senator Simon Lalong, and the Chief of Defence Staff, General Christopher Musa, who led the service chiefs in attendance.
Service chiefs present included the Chief of Naval Staff, Vice-Admiral Emmanuel Ogala, Inspector-General of Police Kayode Egbetokun, Comptroller-General of the Nigerian Immigration Service, Mrs Kemi Nandap and Controller-General of the Nigerian Correctional Service, Sylvester Nwakuche, among others.00
The service came days after the government unveiled the official theme and some of the activities slated for the 2025 Independence celebrations.
This year’s anniversary is tagged “Nigeria @ 65: All Hands on Deck for a Greater Nation,” as announced by the Director of Information and Public Relations at the Office of the Secretary to the Government of the Federation, Segun Imohiosen, in a statement on Wednesday.
“As part of activities to mark the 65th Independence Anniversary, the Juma’at Prayer and the Inter-Denominational Church Service will be held on Friday, 26th September at 1 pm and Sunday, 28th September at 10 am respectively, as well as the World Press Conference on Monday, 29th September at 10 am,” he said.
The Tide source had earlier reported that President Bola Tinubu, alongside former Heads of State, Yakubu Gowon, Olusegun Obasanjo and Goodluck Jonathan, is expected as a special guest at a national discourse convened by the Island Club, Lagos, to mark Nigeria’s 65th Independence Anniversary.
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