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Fatty Acid, Skin Odour Make People Prone To Malaria – Study

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A research study published in Cell magazine has revealed why some people are prone to malaria than others.
While its impossible to hide from a female mosquito —the study revealed that mosquitoes track our carbondioxide exhalations, body heat, and body odor of persons they bite more often than others.
The study described these group of persons as”mosquito magnets” who get more than our fair share of bites.
It revealed that blood type, blood sugar level, consuming garlic or bananas, being a woman, and being a child are all popular theories for why someone might be a preferred snack for mosquitoes.
Though there are still grey areas here says Leslie Vosshall, head of Rockefeller’s Laboratory of Neurogenetics and Behavior.
Lead researchers Vosshall and Maria Elena De Obaldia, a former postdoc in her lab, set out to explore the leading theory to explain varying mosquito appeal: individual odor variations connected to skin microbiota. They recently demonstrated through a study that fatty acids emanating from the skin may create a heady perfume that mosquitoes can’t resist.
“There’s a very, very strong association between having large quantities of these fatty acids on your skin and being a mosquito magnet,” says Vosshall, the Robin Chemers Neustein Professor at The Rockefeller University and Chief Scientific Officer of the Howard Hughes Medical Institute.
In the three-year study, eight participants were asked to wear nylon stockings over their forearms for six hours a day. They repeated this process on multiple days. Over the next few years, the researchers tested the nylons against each other in all possible pairings through a round-robin style “tournament.”
They used a two-choice olfactometer assay that De Obaldia built, consisting of a plexiglass chamber divided into two tubes, each ending in a box that held a stocking. They placed Aedes Aegypti mosquitoes — the primary vector species for Zika, dengue, yellow fever, and chikungunya — in the main chamber and observed as the insects flew down the tubes towards one nylon or the other.
By far the most compelling target for Aedes aegypti was Subject 33, who was four times more attractive to the mosquitoes than the next most-attractive study participant, and an astonishing 100 times more appealing than the least attractive, Subject 19. advertisement
The samples in the trials were de-identified, so the experimenters didn’t know which participant had worn which nylon. Still, they would notice that something unusual was afoot in any trial involving Subject 33, because insects would swarm towards that sample. “It would be obvious within a few seconds of starting the assay,” says De Obaldia. “It’s the type of thing that gets me really excited as a scientist. This is something real. This is not splitting hairs. This is a huge effect.”
The researchers sorted the participants into high and low attractors, and then asked what differentiated them. They used chemical analysis techniques to identify 50 molecular compounds that were elevated in the sebum (a moisturizing barrier on the skin) of the high-attracting participants. From there, they discovered that mosquito magnets produced carboxylic acids at much higher levels than the less-attractive volunteers. These substances are in the sebum and are used by bacteria on our skin to produce our unique human body odor.
To confirm their findings, Vosshall’s team enrolled another 56 people for a validation study. Once again, Subject 33 was the most alluring, and stayed so over time.
“Some subjects were in the study for several years, and we saw that if they were a mosquito magnet, they remained a mosquito magnet,” says De Obaldia. “Many things could have changed about the subject or their behaviors over that time, but this was a very stable property of the person.”

By: Kevin Nengia

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Who Unveils Plans To Check HIV/AIDS Discrimination

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The World Health Organisation (WHO) at the 2024 International AIDS Conference, has released a technical brief titled, “Ensuring Quality Health care by reducing HIV-related Stigma and Discrimination.”
This technical brief is designed to assist health facility managers in providing quality, stigma-free services, and reinforcing the principle that every individual has the right to the highest attainable standard of physical and mental health.
The world health apex body observed that stigma and discrimination still remain significant barriers to accessing HIV-related care.
It noted that these barriers particularly affect key populations, hindering the uptake of and access to health services along the HIV services continuum.
There is a growing body of evidence demonstrating that effective interventions in the health sector can mitigate these issues by focusing on actionable drivers and facilitators of health-related stigma and its manifestations..
To ensure that people living with or affected by HIV can access and stay engaged in care, it is critical that health care workers have the skills to deliver quality stigma-free health services,” said Dr Meg Doherty, Director of WHO Global HIV, Hepatitis and STIs Programmes.
WHO’s technical brief emphasizes the necessity of integrating measures to improve the quality of health care and reduce stigma, ensuring everyone can access the services they need without fear of discrimination.”
The technical brief consolidates existing knowledge, outlines priority areas, describes key actions, and provides country examples to achieve quality, stigma-free health services. While the brief is primarily focused on the health facility level, it is also applicable to community service delivery models.

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Natural Recipe For Longer Life

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Natural Herbs
By Kelvin Nengia

Costa Rica is home to one of the world’s Blue Zones, where people live longer and healthier lives than average. The region of Cartago, called Llano Grande is known for its rich agriculture.
According to a cookbook author and cooking teacher a diet of “pura vida”, lifestyle is our secret to longevity.
Beans
Beans are a great source of protein, fiber, complex carbohydrates, prebiotics, vitamins and minerals. They have been linked to reduced risk of chronic diseases like heart disease and diabetes.
Black and red beans are the most popular, usually served as part of a casado (our traditional dish of rice, beans, veggies and protein) or as a soup consisting of beans and vegetables.
Chickpeas and lentils are popular there and can be used as a substitute for the traditional black beans.
Fresh Fruit and Vegetables
Fruit and vegetables in Costa Rica are generally eaten fresh, not out of a can or a freezer. We typically get our fruits and veggies from local markets called verdulerias.
Some of the most common ones in their diet are papaya, mango, banana, watermelon, pineapple and passion fruit, and they are either eaten on their own or made into drinks and juices.
They use a variety of vegetables in Costa Rican cooking, including potatoes, carrots, tomatoes, avocado, onion, beets, yucca and zucchini. Veggies are either eaten raw, in simple salads dressed with lime, or prepared as picadillo, chopped and boiled, occasionally with some animal protein mixed in for flavor.
Picadillo de chayote is probably another favorite. Chayote is a type of squash that is native to Central and South America, and not very common in the United States. It is green and crisp, and it tastes similar to a jicama.
Rice and Corn
Grains like rice and corn are present in diet Costa ricans but mainly as a complement to the beans and vegetables that we eat.
For instance, the tortillas are used to eat the picadillo popularly called “gallos.” Arroz con pollo is a traditional Costa Rican dish consisting of rice, a lot of chopped vegetables and different pieces of chicken.
This meal is a very popular at celebrations like birthdays, but it is also very commonly enjoyed day to day.
Coffee
In Costa Rican coffee is known for being high in antioxidants, which can help reduce inflammation. Sugary drinks are generally not a big part of the coffee-drinking culture.
Coffee here is enjoyed black or with a bit of milk. And as much as any other meal, a cup is best enjoyed slowly — we do take our time to drink.
It’s a favorite Costa Rican longevity recipe.
They eat rice and beans, either black or red, two to three times a day. For lunch this meal is called casado. For breakfast, it is called gallo pinto and consists of rice and beans mixed with onions, peppers, and cilantro, accompanied with corn tortillas and coffee.
Thanks to its combination of whole grains, protein, amino acids and antioxidants, longevity researcher and Blue Zones founder Dan Buettner considers gallo pinto to be the healthiest breakfast in the world. It is amazing how such a simple dish can be packed with so many health benefits.

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55 Million Battle Dementia as WHO PLANS To Check Disease

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The World Health Organisation(WHO) says currently, more than 55 million people have dementia worldwide with over 60%  living in low- and middle income countries.

It also revealed that every year, there are nearly 10 million new cases.

The revelation came as WHO Assembly endorsed a global action plan on the public health response to dementia 2017-2025.

The goal of the action plan is to improve the lives of people with dementia, their carers and families, while decreasing the impact of dementia on them as well as on communities and countries.

The action plan includes seven strategic action areas, including one on dementia risk reduction,as  there is no cure for dementia currently.

The body stressed that risk reduction for dementia remains critically important with potentially modifiable risk factors means that prevention of dementia is potentially possible by implementing a set of key interventions. This would, in turn, offer opportunities to influence future dementia incidence.

To this end, WHO released guidelines for risk reduction of cognitive decline and dementia in 2019. The guidelines provide health care providers as well as governments, policy-makers and other stakeholders with evidence-based recommendations on health  behaviours and interventions to delay or prevent cognitive decline and dementia.

Since the initial release of the guidelines, the field has evolved significantly, with more evidence now being available. In line with WHO standard procedure, the Department of Mental Health, Brain Health and Substance Use has started the process of updating the guidelines for risk reduction of cognitive decline and dementia with the advice of a Guideline Development Group (GDG).

Meanwhile, experts are proposing to join the GDG for updating the guidelines for risk reduction of cognitive decline and dementia based on their technical expertise, diverse perspectives, demographic background, lived experience and geographic representation

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