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How Brain Inflammation May Aid Autism 

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Autism, a disease of serious developmental disorder that impairs the ability of a person to communicate and interact, may be caused by inflammation of the brains of young people, according to research published in Science Translational Medicine recently.
Prior to the origins of many neurodevelopment disorders, which remain uncertain, the new study of post-modern brain tissue from children who died between the ages of one and five has shown how inflammation affects the brain.
For the first time, researchers from the University of Maryland School of Medicine (UMSOM)  discovered that inflammation alters the development of vulnerable brain cells and this could have mechanistic links to neurodevelopmental disorders and could lead to treatments for many different childhood  – on set neurodevelopmental disorders.
The UMSOM’s Institute for Genome Sciences (IGS), Department of Pharmacology and the University of Maryland Medicine Institute of Neuroscience Discovery (UM – MIND) conducted the research. The study is part of a collection of nearly 30 papers describing the development and diversity of cell types in the human brain.
Though previous research had shown that babies born with abnormalities of the cerebellum frequently go on to experience neurodevelopmental disorders, the new study specifically looked at the cerebellum because it is one of the first brain regions to begin developing and one of the last to reach its maturity, but remained understudied.
The lead author of the research team, IGS Scientist and Associate Professor in the Department of Psychiatry at UMSOM, Seth Ament, Ph.D, stated that, “with the fairly new technology of single nucleus RNA sequencing, we could look at the cell level and see changes in the brain”. Also, the Co – Leader of the research team, the James and Carolyn Frenkil Dean’s Professor and Chair in Pharmacology and Director of UM – MIND, Margaret McCarthy, Ph.D,added, “This has never been done before in this age group and in the context of inflammation.  The gene expression in the cerebella of children and inflammation were remarkably consistent”.
From the report,  the researchers examined donated post mortem brain tissues of 17 children who died when they were one to five years old, eight from conditions that involved inflammation and nine from accidents.
None of the donors had been diagnosed with a neurological disorder prior to death. The two groups were similar in age, gender, race/ethnicity and time since death.  These unique brain tissue specimens had been collected over many years by UMSOM researchers at the University of Maryland Brain and Tissue  Bank.
According to the study, two specific, yet rare types of cerebellar neurons were most vulnerable to brain inflammation  – the Golgi and  Purkinje neutrons. At the single cell level, these two types of neurons showed premature disruption of their maturation.
Dr Ament said, “although rare, Purkinje and Golgi neutrons have critical functions. During development, Purkinje neurons form synapses connecting the cerebellum to other brain regions involved in cognition or emotional control, while Golgi neurons  coordinate communication between cells within the cerebellum. Disruption of either of these developmental processes could explain how inflammation contributes to conditions like autism spectrum disorders and schizophrenia”.
Also, the UMSOM Dean, who is also Executive Vice President for Medical Affairs, UM Baltimore, Dr. Mark Gladwin said, “this study is one of the first to show that gene expression challenges during inflammation which may set the stage for later cellular dysfunction,such as reducing synaptic connectivity or altering energy metalbolism.
“It is critical to understand these mechanisms and changes at the cellular level during brain development in the hope that someday we can develop treatments for neurodevelopmental disorders “, stated a distinguished professor at UMSOM, Akiko Bowers.
However, more studies indicate that the rate of autism is rising. A growing area of research focuses on interaction of genetic and environmental factors. It is likely that a woman’s exposure to harmful contaminants during pregnancy may trigger a genetic mutation leading to autism in her child.  No link has been found between autism and vaccines, including those containing thimerosal, a mercury based compound.
Other environmental factors that may be associated with autism include advanced parental age as at time of conception, pre natal exposure to air pollution or certain pesticides, maternal obesity, diabetes or immune system disorders, extreme prematurity or very low birth weight and any birth difficulty leading to periods of oxygen deprivation to the baby’s brain.
People with autism have trouble with communication . They have trouble understanding what other people think and feel.  This makes it hard for them to express things, either with words or through gestures, facial expressions and touch.
People with autism may have problems with learning.  Their skills might develop unevenly.  They could have trouble communicating but be unusually good at art, music, mathematics or things that involve memory. Because of this, they might do especially well on tests of analysis or problem solving.
More children are diagnosed with autism now than ever. But the latest numbers could be higher because of changes in how its diagnosed, not because more children have the disorder.
According to Key Autism Statistics, as of 2023, in the US, around 1 in 36 children has been diagnosed with autism.  Around 75 million people have autism spectrum disorder, that is 1 percent of the world’s population. 1 in 100 children are diagnosed with autism as of 2021. Autism prevalence has increased 178 percent since 2020. The country with the highest rate of diagnosed autism in the world is Qatar and the country with the lowest rate is France . Also, around 4 times as many boys have autism as girls.

By: Ibinabo Ogolo

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Effect Of Pornography On Children’s Health

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One social vice bedevilling children and adolescents in the world currently is the issue of addiction to pornography. It has assumed a frightening dimension as the recent upsurge in rape and other sexual assault cases are remotely linked to the unlimited access to pornographic materials to impressionable minds.
Pornography is the representation of sexual behaviour in books, pictures, status, films and other media that is intended to cause sexual excitement.
Exposure to pornography harms children and youth by normalising sexual violence and creating unrealistic behaviours.
Consequently, child pornography is on the increase globally and this is a real problem. It is a ‘big deal’ and has significant consequences on the future of children.This problem has increased because of the use of the internet and smart phones.
According to statistics, in 2008, the internet marketing firm, Hitwise, reported that globally, 40,634 web sites distributed pornographic materials. A report according to PornHub in 2020, the word “teen” topped the pornography mega site’s search terms for over six years running, making child pornography one of the fastest growing online businesses with over 55 percent of victims just 10 years old or younger.
In 2010,survey of English students between 14 and 16 years old, almost one third claimed that their first exposure to internet pornography was at 10 years. In a 2011 survey, 31 percent of adolescent boys admitted visiting websites that are intended as Adults only.
In 2012, Australian study of pornography users found out that the first exposure of children was between the ages of 11 and 13 years old. Also, in 2017, Australian Institute of Family Studies in a research by Antonia Quasars and Alissar El- Murr, revealed that nearly half of children  between the ages of 9 and 16 experience regular exposure to sexual images. Moreso, young males are more likely than females to deliberately seek out pornography and they do so frequently.
In Nigeria, internet pornography has continued to grow.Nigeria is a signatory to several international and legal instruments in the involvement of children in pornography. Nigeria has no national laws prohibiting pornography,but, the Cybercrime (Prohibiting Prevention) Act in 2015 only bans child pornography.
Currently, Nigeria has the highest number of internet pornography viewers of any country in Africa.According to reports, Nigerian youths secretly watch pornography and have become addicted largely unknowingly.  Available  statistics show that among Nigerian children, primary consumers of pornography are boys between the ages of 12 and 17 which might be due to the children’s reliance on pornography as primary source of sex education.
According to a counsellor, Justina Amalokwu, “for decades, Nigerian parents have become reluctant to talk about sex with their children . Maybe they are religious or uncomfortable about the topic . This reluctance has pushed many children to turn to the internet for lectures and demonstration on sex. When they go online, they easily get to porn sites”.
Recently, the United Nations International  Children’s Educational Fund (UNICEF) in a statement, stated that it was alarmed by the massive quantity of pornography available online, including graphic and extreme content that is easily accessible to children of all ages. It also stated that efforts to regulate content and restrict children’s access to pornography have not kept pace with technological shifts.
UNICEF however, supports the efforts of government round the world to ensure that children and young people are protected from harmful content in accordance with the convention on the rights of the child and the authoritative guidance from the committee in the Rights of the child .
The American College of Paediatricians on their part has urged healthcare professionals worldwide to communicate the risk of pornography use to parents and their families and to offer resources both to protect their children from viewing pornography and to treat individuals suffering from its negative effects.It said that children under 12 years old, who have viewed pornography, are statistically more likely to sexually assault their peers and these children are at the risk of a broad range of maladaptive behaviours and psychopathology.
A recent primary research article in JAMA psychiatry, shows that pornography consumption is associated with decreased left striatua activation and lower functional connectivity  to the prefrontal cortex. Also,smaller grey matter volume in the viewers can cause down regulation of the brain’s response to erotic material. These neural changes in the brains of pornography users are similar to changes seen in the brains of individuals addicted to cocaine, alcohol and methamphetamines. These cause mental disturbance and unrest for the young school age child .
The Association  advises that since the internet is the primary medium for pornography exposure, computers should be equipped with internet filtering and monitory software to reduce exposure. “There are variety of parental controls and filtering systems available to parents and some current software vendors offering filtering and monitoring of smart phones which are now the primary technology used by adolescents to access the internet.  Also, there are software services which offer the ability to create accountability partnerships so as to increase the success of breaking free from pornography addiction”, the Association noted.
A clinical/school  social worker, Danny Huerta, over the years observed that pornography  leaves children incredibly stunted in their growth and maturity and enslaved to pleasure and consumption, depriving them of healthy sexuality for their marriages for society and for generations to come. He added that pornography triggers the body production of oxytocin, which is the bonding activity between a husband and wife. The more it is used outside the design, the more confused and washed down the ability to bond.
He urged parents to help their children learn how and why to guard their hearts and minds which are their springs of life and to help them see that there is more to life than sex.
Another Child counsellor, Jennifer Michelle Greenberg, said that the consequences of pornography can be disastrous.
“Porn can stay in your head forever. It is very hard to get these images out of your head. They are burned in your memory  like a brand.” She adivised parents to protect their children by teaching them about sex before someone else does.
“According to her, “make it clear to them that if they have any questions or concerns, they can come to you and you won’t be upset. Tell your children that photos and videos of sex and nudity are wrong and teach them  what God’s word says about their bodies”.
“Be aware that many children encounter pornography at the home of a friend or neighbour. Monitor your children online activities and texts. Know what websites they visit, who they are talking to and what their passwords are. Be aware of the images they are taking of themselves and sharing ,”she said.
There is no doubt that exposure of children and adolescents to pornographic materials is harmful to their development and societal growth. Victims of early exposure to such things often end up addicted to it and they tend to want to have multiple sex partners. They are encouraged by what they see to engage in unsafe sexual practices.
It is important that parents give their children moral and sex education from early stages of life. Also, education about internet safety is key in achieving parental control.
Government also has a greater role to play by enforcing laws concerning exposure of children to pornographic materials. It is often a common sight of children and adolescents watching rated videos shown by video rental shops across Nigeria.
Furthermore, introduction of moral and sex education in the curriculum of primary and secondary schools will go a long way in curbing this unhealthy trend and save our youths and the society at large from the menace of pornography.

Ibinabo Ogolo

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Youths’ Role In NationBuilding

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Nation building is a dynamic process involving all segments of the locality, including the often-overlooked and undermined youth population. Youths represent a vast and often untapped resource for immediate and long-term community development efforts. They also provide an invaluable resource for the progress of any society as well as its development. As youths are brought into and connected with national issues and programmes (they have often times been ignored/excluded), they can participate actively and contribute to decision-making at multiple levels.
As youths are engaged in more sustained positive relationships with adults, other youths and national development programmes, apart from realising that they are valued citizens of their nations, such collaborations and participation may lead to skill enhancement, empowerments and confidence-building traits, which will help prepare them for active interest and involvement in nation-building (even in future).
The total population of those between the ages of 15 and 34 was about 30 million in the 1991 census, equivalent to one of every three Nigerians. It was projected that by the year 2000, the total population of this category of young person’s would be about 38 million (National Youth Policy, 2001). In 2006, a nation-wide population and housing census was conducted to update the records. It indicated that the youth profile in the Nigerian population has tremendously improved to 53 million (NPC, 2006).
Apart from the issue of numerical strength, global trend is towards emphasising the primacy of youth in the developmental process, with deliberate efforts by national governments to create conditions that will encourage youth to utilise their energies and resourcefulness for growth and sustainable development of their nations. It was in the light of this development that the Nigerian Youth Organisations in their memorandum to the last National Political Reform Conference maintained that:
“Nigerian youth must have a voice and must be given a greater say to contribute in the way he is governed and allowed to play greater role in leadership and governance so that at all times, he is properly equipped to assume the mantle of leadership which inevitably must come someday. (National Political Reform Conference 2005:15).
However, the prevailing conditions in much of the developing nations, especially Nigeria, have seriously extenuated the potentials of the youth as agents of social change. These challenges range from the economic and social to the cultural. The treacherous triangle of poverty, illiteracy and unemployment in which the bulk of Nigerian youths are currently trapped, has severally challenged their sensibility and has in the long run given rise to what sociologists term as attitudes of fatalism, resignation and acceptance of the situation (Heralambos, 2001). The persistence of these social problems has created an environment where youth are cheaply available for manipulation by self-seeking politicians. Poverty, illiteracy and unemployment are interrelated conditions that generate human needs and therefore constitute a state of deprivation.
As the youth continue to remain in this state, there is pent-up emotions and untapped energies. They provide cheap labour to execute the design of political gladiators and ethnic champions. In an apparent indictment of the Nigerian politicians, Togbolo (2006) observed, “they take advantage of the poverty-stricken nature of the country to exploit the people; politicians are fond of using the youth restive nature as a political strategy to have their way.”
According to Gribble (2010), “more than half of the world’s population under the age of 25 (between ages 15 and 24) are in greatest need of empowerment, those who are younger will quickly come of age and share these same needs. This segment of the population (15 to 24) is expected to continue growing faster than other segments for at least 20 more years” (Gribble, 2010). With the swelling wave of young people, access, empowerment and their engagement in nation-building becomes critical if they are to contribute effectively.
Uhunmwuangbo and Oghator (2013) suggested two (2) major motivations which have brought the converge of youth (young persons) into the policy agenda of national governments, thus fascinate and prioritised youth inclusion to the building process of any nation. According to them, the first is the global process of democratisation, beginning in Southern Europe, extending to Latin America, Asia and Africa, and more recently to Eastern Europe (Almond, 2004).
The second is the phenomenon of globalisation that has seriously challenged the capacity of nation-state to govern and which, according to Heady, et al, embodied a transformation of the spatial organisation of social relations and transaction (Heady, 1979). The combined effects of these global trends have confronted and dismantled authoritarian regimes in a decisive way, and at the same time rekindled the spirit of civil society in the political process (Suleiman, 2006).
The youth as an important component of the civil society is in the process of self rediscovery in an era characterised by the intense movement of the social forces of democratisation and globalisation. As they interact with other actors in the social system, the youth express their interest and needs, they relate with relevant political institutions and political processes to articulate their views and promote shared interest (Suleiman, 2006).
The role of education positioning and providing youth with access to effective engagement in national development which is a way of incorporating them in the decision-making process of the nation’s governance, nation-building activities where they are welcomed, with accurate and comprehensive information which will empower them to make healthy decisions.
There is no how the untapped capacities in youth can be tapped and utilised with an all-inclusive, participatory and synergy approach; thus, a suggestive dimension for involving the youth in nation-building. Youth participation, according to Cornwall (2010), refers to the involvement of youth in responsible, challenging action that meets genuine needs, with opportunities for planning and/or decision-making affecting others in an activity whose impact or consequence is extended to others. i.e outside or beyond the youth participants themselves. Rajani (1999) notes that, “it is only through participation that youth develop skills, build competencies, form aspirations, gain confidence and attain valuable resources.” This shows that youth participation therefore is a product and strategy of sustainable human development.
Youth comprise nearly 30 per cent of the world’s population. These large members of young people are an opportunity; an investment to their country. Youth participation in nation-building programmes/activities therefore is to: Strengthen young people’s abilities to meet their own subsistence needs; prevent and reduce vulnerabilities to economic, political and socially unstable environemnts; promote owership and sustainability of change interventions; help gain entry into target communites and build up trust and social cpaital.
Nigeria with over 140 million people and over fifty percent of youths cannot afford to lock out the youths if they must compete politically, technologically and scientifically in order to align itself with the sustainable development in Africa in particular and the developed world in general. Nigeria can build a strong and viable nation if and only if there is an existence of common values, beliefs, attitudes, effective leadership and a will to live together as a nation. Such transformations must allow every group (especially the youth population) to participate in the economic, political and the social spheres of the nation.
The following recommendations are discernibly based on the foregoing: Youth should be given the opportunity to develop their capacities thrugh balanced education and exposure. Skills acquisition and entrepreneurship will help reduce idleness among youths and keep them from being involved in crime and other activities that are counterproductive in nation-building. Youths should be made relevant and involved in leadership at different levels of government. We must moderate our demands on our youths and as well condition their behavior in line with our cultural values.
The youth of today must not fail this nation.
Concluded

Immanmuel Rohi
Rohi is a member of the Nigerian Youth Volunteers, Rivers State.

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‘How You Go Forward Is Your Responsibility’ 

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What happened to you was not fair. You were merely a collateral damage on someone else’s war path, an innocent bystander, who got wrecked out of proximity.
We are all hurt by life, some of us from egregious wrongdoings, others by unprocessed pain and sidelined emotions. No matter the source, we are all handed a play of cards, and sometimes, they are not a winning hand.
Yet what we cannot forget is that even when we are not at fault, healing in the aftermath will always fall on us and instead of being burdened by this, we can actually learn to see it as a rare gift.
Healing is our responsibility because, if it is not an unfair circumstance it becomes an unlived life.
Healing is our responsibility because unprocessed pain gets transferred to everyone around us, and we are not going to allow what someone else did to us to become what we do to those we love.
Healing is our responsibility because we have this one life, this single shot to do something important.
Healing is our responsibility because if we want our lives to be different, sitting and waiting for someone else to make them so, will not actually change them. It will only make us dependent and bitter.
Healing is our responsibility because we have the power to heal ourselves, even if we have previously been led to believe we do not.
Healing is our responsibility because we are uncomfortable, and discomfort almost always signals a place in life in which we are slated to rise up and transform.
Healing is our responsibility because every great person you deeply admire began with every odd against them, and learned their inner power which had no match for the worst of what life could offer.
Healing is our responsibility because “healing” is actually not returning to how and who we were before, it is becoming someone we have never been, someone stronger, someone wiser, someone kinder.
When we heal, we step into the people we have always wanted to be. We also are not only able to metabolise the pain, we are able to effect real change in our lives, in our families, and in our communities. We are able to pursue our dreams more freely. We are able to handle whatever life throws at us, because we are self-efficient and assured. We are more willing to dare, risk, and dream of broader horizons, ones we never thought we would reach.
The thing is that when someone else does something wrong and it affects us, we often sit around waiting for them to take the pain away, as though they could come along and undo what has been done.
We fail to realise that in that hurt, we had the most important lessons of our lives and the fertile breeding ground upon which we can start to build everything we really want.
We are not meant to get through life unscathed.
We are not meant to get to the finish line unscarred, clean and bored.
Life hurts us all in different ways, but it is how we respond and who we become that determine whether a trauma becomes a tragedy, or the beginning of the story of how the victim became the hero.
Culled from January Nelson.

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