The World Health Organization (WHO) yesterday published a report highlighting the first-ever list of fungal “priority pathogens” – a catalogue of the 19 fungi that represent the greatest threat to public health.
The WHO fungal priority pathogens list (FPPL) is the first global effort to systematically prioritize fungal pathogens, considering the unmet Research and Development (R&D) needs and the perceived public health importance. The WHO FPPL aims to focus and drive further research and policy interventions to strengthen the global response to fungal infections and antifungal resistance.
Fungal pathogens are a major threat to public health as they are becoming increasingly common and resistant to treatment with only four classes of antifungal medicines currently available, and few candidates in the clinical pipeline. Most fungal pathogens lack rapid and sensitive diagnostics and those that exist are not widely available or affordable globally.
The invasive forms of these fungal infections often affect severely ill patients and those with significant underlying immune system related conditions. Populations at greatest risk of invasive fungal infections include those with cancer, HIV/AIDS, organ transplants, chronic respiratory disease, and post-primary tuberculosis infection.
Emerging evidence indicates that the incidence and geographic range of fungal diseases are both expanding worldwide due to global warming and the increase of international travel and trade. During the COVID-19 pandemic, the reported incidence of invasive fungal infections increased significantly among hospitalized patients. As the fungi that cause common infections (such as candida oral and vaginal thrush) become increasingly resistant to treatment, risks for the development of more invasive forms of infections in the general population are also growing.
“Emerging from the shadows of the bacterial antimicrobial resistance pandemic, fungal infections are growing, and are ever more resistant to treatments, becoming a public health concern worldwide” said Dr Hanan Balkhy, WHO Assistant Director-General, Antimicrobial Resistance (AMR).
Despite the growing concern, fungal infections receive very little attention and resources, leading to a scarcity of quality data on fungal disease distribution and antifungal resistance patterns. As a result, the exact burden of fungal diseases and antifungal resistance, are unknown, and the response is therefore undermined.
BY; Kevin Nengia
US Moves Against Children’s Pain Killers
The US Centre for Disease Control and Prevention has begun moves to check use of painkillers in children.
Already certain over-the-counter children’s medications are hard to find in many places across the United States.
The availability of children’s painkillers first started dropping in June. After some recovery in early fall, it started to dip again in November, according to market research firm Nielsen IQ, which tracks point of sale data from retailers.
The US Food and Drug Administration said it is closely working with drug manufacturers to assess the situation.
“The FDA recognises the potential impact that reduced availability of certain products may have on health care providers and patients. While the agency does not manufacture drugs and cannot require a pharmaceutical company to make a drug, make more of a drug, or change the distribution of a drug, the public should rest assured the FDA is working closely with numerous manufacturers and others in the supply chain to understand, mitigate and prevent or reduce the impact of intermittent or reduced availability of certain products. The FDA understands that manufacturers expect availability to continue to increase in the near future,” the agency said.
According to Seattle Children’s Hospital, the continuing surge of respiratory illnesses has affected liquid acetaminophen and ibuprofen, which are commonly given to children.
“We are actively implementing mitigation strategies for the shortages of these fever reducing medications,” said Emily Benefield, manager of pharmacy clinical programs at Seattle Children’s.
A Kroger spokesperson told CNN its pharmacy team is working “diligently to ensure our customers have the medications they need. At this time, our inventory of children’s acetaminophen and ibuprofen are constrained. We continue to work daily to manage through the constraints.”
Johnson & Johnson says it’s seeing high demand for its pain relief products and is working to maximize production capacity.
“We are doing everything we can to make sure people have access to the products they need, including maximizing our production capacity, and running our sites 24 hours a day, 7 days a week. Some products may be less readily available due to this increased demand but we are not experiencing an overall shortage of Children’s Tylenol or Children’s Motrin in the United States,” the company said in a statement Friday. “We will continue to work with our retailers to provide these products throughout the Cold and Flu Season.”/
Despite the increased demand, retail pharmacy Walgreens said, it is “prepared and able to continue meeting the needs of our customers and patients.”
“We are working with our diverse set of suppliers and distributors to ensure our patients have the products they need most,” the company said.
New Drug Shows Promise Against Alzheimer
A new drug to slow the destruction of the brain from Alzheimer’s disease has been hailed as promising.
The research breakthrough ends decades of failure and shows a new era of drugs to treat Alzheimer’s disease-the most common form of dementia – is possible.
Yet the medicine, lecanemab, has only a small effect and its impact on people’s daily lives is debated.
And the drug works in the early stages of the disease, so most would miss out without a revolution in spotting it.
Lecanemab attacks the sticky gunge – called beta amyloid – that builds up in the brains of people with Alzheimer’s.
For a medical field littered with duds, despair and disappointment, some see these trial results as a triumphant turning point.
Alzheimer’s Research UK, said the findings were “momentous”.
One of the world’s leading researchers behind the whole idea of targeting amyloid 30 years ago, Prof John Hardy, said it was “historic” and was optimistic “we’re seeing the beginning of Alzheimer’s therapies”. Prof Tara Spires-Jones, from the University of Edinburgh, said the results were “a big deal because we’ve had a 100 percent failure rate for a long time”.
Currently, people with Alzheimer’s are given other drugs to help manage their symptoms, but none change the course of the disease.
Lecanemab is an antibody – like those the body makes to attack viruses or bacteria – that has been engineered to tell the immune system to clear amyloid from the brain. Amyloid is a protein that clumps together in the spaces between neurons in the brain and forms distinctive plaques that are one of the hallmarks of Alzheimer’s.
Getting Trimmed Naturally 1
There are a lot of misconceptions about weight gain. The first is that weight gain comes from extra calories we do consume that we don’t expend. Experts say we eat too much and exercise little. So if one get fatter then surely he or she must be eating too much.
The other misconception is that once we cut our food then we will naturally become trimmed. All these are hinged on the diet theory, which only works for some time.
Over the past 40 years studies have shown that you can’t get clinically significant effect from cutting down on your calories. Even though experts are saying that sloth is responsible for weight gain- they overlook one basic truth that dieting only works for a short period.
The new study that seems to break those myths about body fat is now revealing some stunning facts. The kind of food we eat makes us fat. Two scientists at University of Pennsylvania, Mitchell Lazar and Cardiologist Allan Sniderman at McGill University all in the USA have shown that that food that we eat often makes us pack in flesh. These include bread, plain baked potatoes, and plain pasta, rice, sweet corn. They confirmed that fatty foods isn’t the enemy but easily digested carbohydrates. While steak, burgers, cheese or sour cream help us lose weight and keep our heart healthy.
This sounds ironical, but it has been discovered that those who do diet and avoid those foods end up getting hungry. What happens is that when you conserve energy or burn less energy, you are bound to add more flesh. Many public health authorities want us to practice energy balance, which is a new way to say that you shouldn’t take more calories than one expends.
No matter how one counts what he or she eats, it is impossible to determine calories and know when we are over board. No matter how good you are at counting calories, you can’t do it. So its couple of sips of soft drinks and few bites of humburger that can make you add weight. That means it at the point when we eat extra than the body want that the body store excess as fat.
The myth of exercising to reduce weight is really making waves. Exercise is helpful but it’s not the main ingredient for fat burning. The phony truth is that the two things we tell people to do in order to lose weight-eat less and exercise more- are the exact two things that make one more hungry. Thus there is need for balance. If one must exercise, then it should be done moderately so as to allow the body to recover the stretch.
The reality is that insulin is the primary hormone that makes one to add weight. If one eats food that spikes insulin like bread, biscuits, sweets, soft drinks. It is refined carbohydrates that raise insulin levels in the body.
To be contd
Explained in simple terms your fat tissue is more like your wallet, and your meals are like going to the ATM. You know how you use the ATM: You put the cash in your wallet and gradually spend it, and when you get too low on cash, you go back to the ATM. It’s the insulin that locks the money in your wallet, so you keep going to the ATM, and your fat cells are getting fatter and fatter. More often you become hungry and you eat again because the insulin can’t get at the fatty acids leading to weight gain.
Low carb diet is key if you are to get trimmed. In Africa where stables are more of carbohydrate it is best to choose those with fibre. It’s difficult to follow the Atkins diet like eating skinless chicken and green salad, melted mozzarella cheese and all those western diet.
An example of a workable diet is to include eggs more often and cut down on processed foods, especially processed carbohydrate. Complex carbohydrate and vegetables have more fibre and makes you get filled quickly. Instead of Irish potato, go for sweet potatoes, oats that have more fibre. I advise people to eat garri than processed plantain and wheat meals. By the way, processed wheat can worsen the body ails.
The other way to go is, to eat low carbohydrate, and that means more of protein, fat, vegetables and complex grains like millet, and beans. With low carbohydrate, one can eat as much and still remain trimmed. A low carbohydrate is better than a low fat, low calorie diet.
Research has shown high fat diet is good for the heart. I don’t mean trans -fat but healthy fats from cheese, milk, olive oil and fish oil. Once your HDL goes up, your LDL goes down and this reduces high cholesterol and inadvertently cuts down excess insulin which is a big factor in fat burning.
The low fat diet which medical authorities promote often in the bid to reduce heart problems is actually bad for the heart as studies reveal. A study published by Readers Digest in February 2011 said, “the public health effort to get everyone to eat that way is one of the fundamental reasons that we now have obesity and diabetes epidemics”.
The strange conclusion is that not everyone gets fat from eating carbohydrates- it has to with how sensitive your fat cells are fight with muscle cells. But the huge percentage of the people who get fat got it in their high carbohydrate diet, especially processed ones. Agreed that getting rid of carbohydrate might not make you lean, but the leanest you can be is on the diet with the fewest carbohydrates.
A low carb diet has lots of health benefits- it can reduce your blood pressure, and it’s advisable to eat more of natural foods than processed foods. Our ancestors ate more of meat, vegetables and fibre from fruits. The fundamental idea is, don’t eat foods that make you fat, beyond that, you can eat as much as you want without much processed carbohydrates.
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