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Oxford University Begins Monkey Pox Vaccine Trial

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A new vaccine to tackle monkey pox is underway courtesy of the Oxford University team credited with finding effective drugs to treat Covid-19.
The project is tagged,” trialling an antiviral called tecovirimat to aid monkeypox recovery”.
So far, more than 3,000 people in the United Kingdom have caught the monkeypox virus in recent months, with more cases expected.
The virus, which is spreading rapidly in other countries as well, has been declared a global health emergency.
The infection typically gets better on its own, but recovery can take weeks and there can be serious complications.
“The aim is to find a treatment that can help people get better quicker and get out of quarantine,” said Professor Sir Peter Horby, one of the “platinum trial “researchers at the University of Oxford.
Around 500 patients will take part in the
trial. Some will be treated twice-daily with tecovirimat tablets while they recuperate from the virus in their own home; others will receive a placebo – or dummy treatment  instead.
By comparing the two groups of volunteers, the researchers hope to have the results for the drug trial within months.
Tecovirimat – also known as Tpoxx – prevents the virus from leaving infected cells, stopping its spread within the body. It was licensed earlier this year for monkeypox, based on promising results from initial studies in animals and evidence of safety in healthy human volunteers
It is caused by the monkeypox virus, a member of the same family of viruses as smallpox, although much less severe.
Infections are usually mild and the risk to the general population low. However, the United Kingdom government has bought stocks of smallpox vaccine to try to halt its spread.
The virus can be spread when someone is in close contact with an infected person.
It has not previously been described as a sexually-transmitted infection, but it can be passed on by close contact.
Anyone with the virus should abstain from sex while they have symptoms.IMAGE SO
Harun Tulunay, 35, from London, was hospitalised with a severe case of monkeypox which included a large lesion on his nose. He was treated with tecovirimat.
“When you are really sick and in pain, you are ready to try anything – but you do want to know if it is going to work or not,” he said.
“I still wanted to take it. And for the first time, my health improved and I started to feel better.
“I don’t want anyone else to become as severely sick as I was.
“This study will help patients who are not in hospital to understand how tecovirimat works, what they can expect, and the time frame of the recovery process.
“Knowing whether there is an effective treatment may also help to reduce any anxiety around monkeypox,” he added.
Minister for Public Health Maggie Throup said: “This government-funded study is an important step to finding a treatment which can help speed up the recovery of those who have monkeypox.
She added: ‘Vaccines remain our best defence against the spread of monkeypox – we urge all those eligible to come forward when contacted, and report any symptoms.

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Alcohol And Drug Interactions

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With rising consumption of alcohol in recent times, experts have advised on cautious use with some drug medications.
Among drugs that do not tally with alcohol are hypertensive and antibiotics medications.
Antibiotics are one class to watch out for. Certain drugs are more concerning than others, so there tends to be confusion about whether it is okay to drink alcohol or not. One to keep an eye on is erythromycin. Erythromycin can increase blood alcohol levels and the effects of drinking, making patients feel more intoxicated than anticipated.
Similarly, taking metronidazole with alcohol might cause a disulfiram-like reaction – leading to nausea and general hangover-like symptoms. There is some controversy over how likely this is to occur, but the general consensus is to avoid drinking while taking metronidazole.
Additionally, patients might not realise that certain antibiotics such as doxycycline might be less effective in patients who are regular drinkers. If patients are not able to stop drinking, providers might consider an alternative drug.
Also talk to patients about antihypertensive drugs. Chronic drinking can cause hypertension. But moderate drinking while taking antihypertensive drugs can increase the effects of these drugs, leading to hypotension.
Additionally, drinking red wine can rapidly increase blood levels of extended-release felodipine and its side effects. Advise patients taking extended-release felodipine to avoid red wine specifically.
There are many other drug-alcohol interactions to watch out for, including interactions with painkillers and antidepressants. There are a lot of factors to consider – you will note in our specific interaction entries that some concerns might only be related to binge drinking, while others might apply only to chronic drinkers.
Culled from Tribuneonline

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Physical Activity, Sports Contribute To Public Health -WHO

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Regular physical activity and sport, such as football, can make a major contribution to improving public health by engaging people in regular, safe and social physical activity in their local communities, the World Health Organisation (WHO) has said.
This is one of the key recommendations outlined in the WHO Global Action Plan on Physical Activity” said Head of the Physical Activity Unit at WHO, Dr Fiona Bull, yesterday.
The Sports Health Conference which is holding ahead of the World Cup in Qatar aims to strengthen global efforts to decrease non-communicable diseases and promote positive mental health and well being.
The three-day conference will feature global sport and health experts, scientists and policy-makers from the Commonwealth Secretariat, the International Olympic Committee (IOC) and the Organisation for Economic Co-operation and Development (OECD).
Together, they will examine how the popularity of sport can be leveraged to benefit health and increase participation in sports, and how mega sports events can leave more sustainable legacies which strengthen community participation in physical activity into the future.
Regular physical activity and sports help prevent and treat NCDs, and can also improve mental health and well-being. NCDs kill 41 million people each year, equivalent to 74percent of all deaths globally. Physical inactivity increases the risk of dying from an NCD. Today, one in four adults and four in five adolescents globally are not active enough and there has been little change in the average levels of physical activity.
Keynote speakers at the Sport for Health conference include: Nasser A. Al-Khori, Executive Director, Generation Amazing Foundation, who will share preparation and plans for the FIFA World Cup Qatar 2022 legacy;  Peter Krustrup (Denmark) who initiated the “Football is Medicine” research consortia  of more than 200 researchers from 26 countries; and Matthew Philpott (UK), Executive Director, European Healthy Stadia Network CIC, who will share insights into how sports stadia venues can contribute to improving public health and raising levels of physical activity among populations.
“We are very happy to partner with the Ministry of Public Health and WHO to shed light on the importance of sport and the ways it can positively impact the health of individuals and communities,” said Executive Director at the Generation Amazing Foundation (GA), Nasser Al Khori, “Over the years, GA has developed programmes and tailored curricula to address a variety of social issues that impact youth and their well-being. We are excited to announce our latest module at the conference, which focuses on mental health and aims to provide sport for development practitioners with the knowledge and tools necessary to help cultivate self-awareness and influence positive behavioural change.”
portant tool for global health promotion. It is versatile, effective, fun and social, and it’s a global language,” said Peter Krustrup. “Football training is optimal for broad-spectrum prevention and treatment of noncommunicable diseases. “
The Sport for Health Conference, and the 4thAnnual Meeting of Football is Medicine (FIM), is co-hosted by the World Health Organization, the Qatar Ministry of Public Health and Generation Amazing Foundation. It is an activity undertaken as part of the Healthy FIFA World Cup Qatar 2022 – Creating Legacy for Sport and Health Initiative, a partnership between WHO, FIFA, State of Qatar (Ministry of Public Health) and Qatar’s Supreme Committee for Delivery & Legacy.

By: Kevin Nengia

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PCN: 1,500 Persons Get Free Medical Services

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The Pharmacy Council of Nigeria (PCN) says no fewer than 1,500 persons benefited from its free healthcare services for indigents in Etsako Federal Constituency in Edo.
The Executive Director, PCN, Dr Achi Thomas, said this at the closing ceremony of the one-week free healthcare services yesterday in Auchi, Etsako West Local Government Area of Edo.
Thomas said that the programme which was facilitated by Hon. Johnson Oghuma, lawmaker representing Etsako Federal Constituency, was to promote the wellbeing of indigent persons at the grassroots.
Thomas said that the outreaches targeted indigent persons in rural communities on key areas such as general consultation, eye diagnosis and treatment, free eye glasses as well as distribution of free drugs.
“During the one-week exercise, medical volunteers carry out diagnosis; treatment, medical procedures; drugs, eye glasses and other medical consumables were also given to patients free of charge.
“So far, we have attended to1500 persons and our target is 2000 persons through our free health medical outreach,’’ he said.
Oghuma commended the council for reaching out to the three local government of its constituency by ensuring that affected persons benefit from the medical outreach.
“This is one of the series of programmes organise by me to touch the lives of the people of my constituency.
“I want the people of my constituency to also embrace any opportunity of free medical care by coming out en-mass to be treated for free,” he said.
Some of the beneficiaries who spoke to the News Agency Nigeria thanked the council and the lawmaker for the gesture.

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