New Serun Trial Set To End Ebola Scourge

A new drug known as ZMapp is being developed by a US Biotech company, Mapp Biopharmaceutical Inc to check the deadly Ebola virus.
This is coming two days after two American humanitarian medical personnel working in Liberia and Sierra Leonne, Dr Kent Brantly and Nancy Writebol were flown to the United States after contracting the virus.
Brantly is said to be back on his feet  after receiving the highly experimental drug. Brantly and Writebol’s conditions significantly improved after receiving the medication, sources say.
Until it was administered on the two medical personnel, ZMapp has not been approved for human use and has not even gone through the clinical trial process, which is standard to prove the safety and efficacy of a medication. It may have been given under the U.S. Food and Drug Administration’s “compassionate use” regulation, which allows access to investigational drugs outside clinical trials.
Getting approval for compassionate use is often long and laborious, but in the case of Brantly and Writebol, they received the medication within seven to 10 days of their exposure to the Ebola virus.
The experimental drug, known as ZMapp, was developed by the biotech firm Mapp Biopharmaceutical Inc., which is based in San Diego. The patients were told that the treatment had never been tried before in a human being but had shown promise in small experiments with monkeys.
According to company documents, four monkeys infected with Ebola survived after being given the therapy within 24 hours after infection. Two of four other monkeys that started therapy within 48 hours after infection also survived. One monkey that was not treated died within five days of exposure to the virus.
Already, the disease has claimed over 1603 lives according to World Health Organisation (WHO) records. The disease has ravaged many West African countries of Liberia, Sierra Leone and recently in Nigeria after a Liberian diplomat, Mr Patrick Sawyer died in Lagos after arriving in the country.
Hope had risen last week after a report indicated that scientists in the country have found cure for the disease. The report claimed a compound from Garcinia Kola (Bitter Kola), a plant commonly eaten in West Africa.
Former Chairman of the Independent National Electoral Commission (INEC), Prof Iwu had led the research with a team of other scientists commissioned by the Bioresources Development and Conservation Programme in the USA.
The research was started 10 years ago, but Prof Iwu, who is currently with the Pharmagnosy Department in the University of Nigeria, Nsukka said the work was inconclusive.
He believed that further trials will lead to development of a drug in the future.
Meanwhile, the Minister of Health, Prof Onyebuchi Chukwu has debunked reports that bitter kola can be used to cure the Ebola Virus Disease (EVD).
“As the minister of health, there is no scientific proof to show that bitter kola can be used for prevention or cure of Ebola virus,” Chukwu said.
He made the disclosure on Monday after a medical doctor who treated Mr Sawyer in Lagos was said to have shown signs of contracting the disease
Already,  health authorities has kept under strict surveillance the 65 persons who made contact with the dead Liberian to avert further spread of the epidemic.
The minister said that efforts were being made to find a vaccine that could help in prevention of the disease and possibly its cure.
He said while health personnel were carrying out screenings at the borders, a technical working group will be inaugurated soon.
He also said directives have been issued that all dead bodies from the three endemic countries, Guinea, Sierra Leone, and Liberia should not be brought back into Nigeria.
The three countries, where more than 1200 people have been infected so far with the deadly virus, have recorded over 700 deaths due to the disease.
Ebola is said to be transmitted from fruit bats and apes to humans who hunt them for food and is further spread to other humans when they come in contact with the blood or body fluid of an infected person.
Symptoms of the disease include fever, headache, chills, diarrhoea, nausea, vomiting, sore throat, backache, and joint pains.
Later symptoms include bleeding from the eyes, ears and nose, bleeding from the mouth and rectum, eye swelling, swelling of the genitals and bloody rashes all over the body. There is no drug or vaccine yet to treat the virus that has an over 60 per cent fatality.