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Tuberculosis Vaccine Research Gets $3m Grant

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Tuberculosis Vaccine Initiative (TBVI) recently received a $3million grant for a three year term from the Bill & Melinda Gates Foundation. This grant enables the nonprofit organization to strengthen its fundraising and communication activities in order to increase awareness and support for tuberculosis (TB) vaccine research and raise funds for the development of safer and more effective vaccines.

In the coming 10 years, TBVI hopes to raise 200 million euros from governments, foundations and private industry for the discovery and early clinical development of new vaccines. Development of new vaccines is crucial because the only existing vaccine, BCG, is not very effective in young adults, the group of people mostly affected by the disease.

“New vaccines are essential to achieve the international aim of a TB-free world in 2050. We need several types, not only for initial protection against TB, but also to boost adolescent immunity and prevent disease in latently infected individuals, “ explains Jelle Thole, director of TBVI. “To enable development of these vaccines, more investment is needed.”

TBVI financially and practically supports and facilitates a growing international network of over thirty universities, institutes and industries involved in research and development of new TB vaccines. The organization evolved from TBV AC, a European Union (EU) funded project to identify good candidates for new TB vaccines. TBV AC has yielded five new TB vaccine candidates, fifteen candidate biomarkers and three candidate adjuvant molecules. These hopeful candidates are now in preclinical development or even clinical phase.

TBVI is extremely pleased with the encouraging new signs of progress on TB. “Because of this funding, we can continue to change new discoveries into real vaccines,” says Joris Vandeputte, senior vice president Fundraising & Advocacy at TBVI. “These vaccines are urgently needed, as the resurrection of TB is a ticking time bomb. Many people believe it is a disease of the past, but in fact it is endangering our future, taking almost 1.8 million lives a year.”

The global burden of TB is slowly falling, but still two billion people; about one third of the world’s population, are estimated to be infected with the mycobacteria that cause TB. Most of them develop a latent infection, with about a 10 per cent risk of developing the infectious disease later in life. People with HIV are 20 times more likely to develop the symptoms once they are infected. Efficient drugs to treat TB are available, but involve a long and burdensome treatment period of up to a year. Additionally, worldwide prevalence of various forms of drug-resistant TB poses an increasing problem and enormous challenges to effective treatment.

With new infections occurring at a rate of one per second, millions of people develop TB symptoms every year. In 2007, there were 9.27 million new cases. 500,000 of those were multi-drug resistant and 50,000 of those were extensively drug resistant.

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RSG Plans Fresh Training For TBAs

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Plans are in the works by the authorities in the Rivers State Ministry of Health to conduct training for Traditional Birth Attendants(TBAs) in the State.
State Commissioner for Health, Dr. Adaeze Oreh gave the hint while chatting with newsmen recently in Port Harcourt.
She said the training has become crucial to school the TBAs on methods and measures to complement in maternal health care.
In her words,”  We are aware of of their roles, but we need to be confident that they can still play that role, especially the skills set needed to complement what government is doing.’’
Dr. Oreh explained that maternal and child care has evolved, hence, the TBAs need to be schooled,” we want them to scale up their skills, especially on high risk pregnancies.”
She continued, “ We want to make sure that our system mops up those high risk pregnancies, because we know that many of them carry out clandestine activities they are not helping us.”
Assuring of improved manpower in the State health sector, Dr. Oreh said the Governor Siminalayi Fubara administration has embarked on fresh recruitment exercise for health workers to meet current challenges.
She assured that once the recruitment exercise is completed, the various health centres and hospitals will be staffed with qualified manpower to provide efficient health services in the State.

Kevin Nengia

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Viral Hepatitis Claims 3,500 Lives Daily -WHO

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The World Health Organisation (WHO) has raised an alarm on viral hepatitis infection that claims 3,500 lives each day.
According to the World Health Organisation (WHO) 2024 Global Hepatitis Report, the number of lives lost due to the viral hepatitis is increasing.
The disease is the second leading infectious cause of death globally — with 1.3 million deaths per year, the same as tuberculosis, a top infectious killer.
The report, released at the World Hepatitis Summit revealed that despite better tools for diagnosis and treatment, and decreasing product prices, testing and treatment coverage rates have stalled.
It, however, said, reaching the WHO elimination goal by 2030 is still  achievable, if swift actions are taken now.
New data from 187 countries show that the estimated number of deaths from viral hepatitis increased from 1.1 million in 2019 to 1.3 million in 2022. Of these, 83percent were caused by hepatitis B, and 17percent by hepatitis C. Every day, there are 3,500 people dying globally due to hepatitis B and C infections.
“This report paints a troubling picture: despite progress globally in preventing hepatitis infections, deaths are rising because far too few people with hepatitis are being diagnosed and treated,” said WHO’s Director-General, Dr Tedros Adhanom Ghebreyesus.
He added, “WHO is committed to supporting countries to use all the tools at their disposal – at access prices – to save lives and turn this trend around.”
Updated WHO estimates indicate that 254 million people lived with hepatitis B and 50 million with hepatitis C in 2022. Half the burden of chronic hepatitis B and C infections is among people 30–54 years old, with 12percent among children under 18 years of age. Men account for 58percent of all cases.
New incidence estimates indicate a slight decrease compared to 2019, but the overall incidence of viral hepatitis remains high.
In 2022, there were 2.2 million new infections, down from 2.5 million in 2019.
These include 1.2 million new hepatitis B infections and nearly one million new hepatitis C infections. More than 6,000 people are getting newly infected with viral hepatitis each day.
The revised estimates are derived from enhanced data from national prevalence surveys. They also indicate that prevention measures such as immunisation and safe injections, along with the expansion of hepatitis C treatment, have contributed to reducing the incidence.

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How Dates Boost Fertility -Research

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Now, researchers in a study, suggest that date palm is an arsenal to fight infertility in couples. They found that 1-month consumption of date palm has a positive impact on the sexual function of infertile couples.
The study to investigate the effect of date palms on the sexual function of infertile couples  was in the 2022 edition of the BMC Research Notes.
In a double-blind, placebo-controlled clinical trial conducted on infertile women and their husbands who were referred to infertility clinics in Iran in 2019, researchers found sexual function in females (arousal, orgasm, lubrication, pain during intercourse, satisfaction) in the intervention group was significantly increased compared to females in the control group that had no date palm.
Infertility and infertility management affects different dimensions of a couple’s life. Sexual dysfunctions can appear in both partners and might provoke problems in every stage of sexual response. Infertility negatively affects the sexuality of infertile couples.
Numerous studies show that infertile women have lower sexual function than fertile women. Sexual satisfaction is strongly affected by the consequences of infertility such as reduced self-esteem, feelings of depression and anxiety, and failed sexual relationships.
The intervention group was given a palm date capsule and the control group was given a placebo. The starch powder was applied to prepare the placebo capsules.
Also, all areas of male sexual function (erectile function, orgasmic function, sexual desire, intercourse satisfaction and overall satisfaction) significantly increased in the intervention group compared to the control group.
Infertility is not only a medical problem but also affects all personal dimensions and social life of most infertile individuals. Infertile couples are more prone to psychological problems (anxiety, depression, and stress), which may result in marital distress, social dysfunction (stigma, social exclusion, and feelings of failure), and reduced quality of life.
Infertility and infertility management affects different dimensions of a couple’s life. Sexual dysfunctions can appear in both partners and might provoke problems in every stage of sexual response. Infertility negatively affects the sexuality of infertile couples.
Numerous studies show that infertile women have lower sexual function than fertile women. Sexual satisfaction is strongly affected by the consequences of infertility such as reduced self-esteem, feelings of depression and anxiety, and failed sexual relationships.
Dates palm is known to have come from what is now Iraq. In Nigeria, dry and soft date fruits are sold out for consumption. However, in the northern part, they are added to the locally brewed alcoholic beverage to help reduce the intoxicating power.
Dates are a good source of energy and vitamins and important elements such as phosphorus, iron, potassium and a significant amount of calcium. It is also rich in phenolic compounds possessing free radical scavenging and antioxidant activity.
Since ancient times, the date palm has been used in Greece, China and Egypt to treat infertility and increase sexual desire and fertility in females. There are few studies on the effect of date palms on male and female sexual function in human beings.
Besides, studies have shown that the various parts of its plant are widely used in traditional medicine for the treatment of various disorders which include memory disturbances, fever, inflammation, paralysis, loss of consciousness and nervous disorder.
Culled from Tribune online.

 

The researchers suggested that the improvement in male and female sexual function can be due to active ingredients and increased levels of sex hormones following the consumption of date palms since studies indicated that increasing sex hormones are effective in sexual function.

They, however, recommended more studies with a longer duration on the use of date palms on sex hormone levels in infertile couples.

Previously, a study revealed that using date palms in postmenopausal women for 1 month had a positive and significant impact on sexual desire and arousal.  Another suggested that using date palms had a positive impact on orgasm, satisfaction and lubrication in women and also reduced pain during intercourse in women.

In the laboratory, administering date palms to male rats and measuring their sexual behaviours, researchers showed that sexual behaviour parameters (number of ejaculations, number of intercourse) increased compared to the control group.

 

 

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